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O uso de sinvastatina associado ao arcabouço de PLGA

RESUMO

Objetivo: realizar uma revisão da literatura para avaliar o impacto da combinação da sinvastatina com arcabouços de ácido polilático- -co-glicólico (PLGA) na promoção da regeneração óssea. Material e métodos: foi realizada uma busca na literatura por artigos que examinaram a sinvastatina como agente osseoindutor em diversas concentrações, associada ao PLGA como osseocondutor, em diferentes configurações de arcabouços, com o intuito de estimular a regeneração óssea. Resultados: foram incluídos na análise seis estudos pré-clínicos realizados em animais e dois estudos in vitro. Dos seis estudos pré-clínicos incluídos, cinco indicaram que a sinvastatina em arcabouços de PLGA pode ter um impacto positivo na regeneração óssea, estimulando a proliferação e diferenciação celular, bem como influenciando a formação de osso em modelos animais. Os estudos in vitro demonstraram maior proliferação celular em arcabouços contendo a sinvastatina. Conclusão: a sinvastatina combinada com arcabouços de PLGA pode ser uma alternativa aos métodos tradicionais de regeneração óssea, sendo eficaz nos estudos incluídos no presente trabalho.

Palavras-chave – Ácido polilático-co-glicólico; Sinvastatina; Osteocondução; Revisão da literatura.


ABSTRACT

Objective: to conduct a literature review to assess the impact of the combination of simvastatin with PLGA scaffolds on promoting bone regeneration. Material and methods: six pre-clinical studies conducted in animals and two in vitro laboratory studies were included in the analysis. These studies examined simvastatin as an osteoinductive agent in various concentrations and PLGA as an osteoconductive agent in different scaffold configurations to stimulate bone regeneration. Results: of the six pre-clinical studies, five indicated that simvastatin associated to PLGA scaffolds may have a positive impact in bone regeneration, stimulating cell proliferation and differentiation. Conclusion: literature shows that the combination of simvastatin with PLGA scaffolds could be an alternative to traditional methods of bone regeneration, proving to be an effective and safe solution in the studies included in this work.

Key words – Poly (lactic-co-glycolic acid); Simvastatin; Osteoconduction; Literature review.

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