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Efeito de um colutório contendo chá verde e ácido hialurônico sobre a saúde peri-implantar

RESUMO

O objetivo desse estudo foi avaliar um colutório à base de chá verde e de ácido hialurônico em pacientes portadores de próteses do tipo protocolo superior ou inferior com pelo menos seis meses em função. Dos 20 pacientes envolvidos no estudo, 17 finalizaram o acompanhamento de dois meses (15 mulheres e dois homens), sendo que nove utilizaram o colutório-teste e oito utilizaram o colutório-controle. Esses pacientes apresentaram 112 implantes no total, sendo que sete apresentaram próteses protocolos superiores, sete apresentaram próteses protocolos inferiores e três apresentaram próteses protocolos superiores e inferiores. Foram analisados quatro sítios por implantes (mesial, vestibular, distal e palatino-lingual) no período baseline e após 60 dias do início da utilização dos colutórios: 1) Profundidade de sondagem (PS); 2) Nível da margem peri-implantar (NMP); 3) Nível clínico de inserção (NCI); 4) Índice de inflamação (II); e 5) Índice de biofilme (IB). Os pacientes apresentavam inflamação peri-implantar e má condição de higiene oral no início do estudo, e todos os pacientes apresentaram redução no IB e II. Os pacientes que utilizaram o colutório-teste apresentaram redução da inflamação em relação aos pacientes que utilizaram o colutório-controle no período de 60 dias. O colutório à base de chá verde e ácido hialurônico promoveu redução da inflamação, que foi associada à redução da quantidade de biofilme em pacientes com próteses totais suportadas por implantes dentários.

Palavras-chave – Biofilme oral; Controle químico; Implantes dentários; Inflamação.

ABSTRACT

The objective of this study was to evaluate a mouthwash based on green tea and hyaluronic acid in patients with complete, arch fixed implant-supported prostheses with at least 6 months in function. Of the 20 patients involved in the study, 17 completed the 2-month follow-up (15 women and 2 men), with 9 using the test mouthwash and 8 using the control mouthwash. These patients presented a total of 112 implants, with 7 patients having upper total arch prostheses, 7 patients with lower total arch prostheses and 3 patients with upper and lower total arch prostheses. Four implant sites were analyzed (mesial, buccal, distal and palatine-lingual) at baseline and after 60 days after the beginning of the mouthwash use: 1) Probing depth (PD); 2) Peri-implant margin level (PML); 3) Clinical attachment level (CAL); 4) Inflammation index (II); and 5) Biofilm index (BI). Patients presented peri-implant inflammation and poor oral hygiene at baseline, and all patients had a reduction in IB and II at the 60-day period of follow-up. Patients who used the test mouthwash showed reduced inflammation compared to patients who used the control mouthwash after 60 days. The mouthwash based on green tea and hyaluronic acid promoted a reduction in inflammation that was associated with a reduction in the amount of biofilm in patients with total arch prosthesis supported by dental implants.

Key words – Oral biofilm; Chemical control; Dental implants; Inflammation.

Referências

  1. Salvi GE, Cosgarea R, Sculean A. Prevalence of periimplant diseases. Implant Dent 2019;28(2):100-2.
  2. Salvi GE, Cosgarea R, Sculean A. Prevalence and mechanisms of peri-implant diseases. J Dent Res 2017;96(1):31-7.
  3. Derks J, Schaller D, Håkansson J, Wennström JL, Tomasi C, Berglundh T. Effectiveness of implant therapy analyzed in a swedish population: prevalence of peri-implantitis. J Dent Res 2016;95(1):43-9.
  4. Lee CT, Huang YW, Zhu L, Weltman R. Prevalences of peri-implantitis and peri-implant mucositis: systematic review and meta-analysis. J Dent 2017;62:1-12.
  5. Stewart B, Shibli JA, Araujo M, Figueiredo LC, Panagakos F, Matarazzo F et al. Effects of a toothpaste containing 0.3% triclosan in the maintenance phase of peri-implantitis treatment: 2-year randomized clinical trial. Clin Oral Implants Res 2018;29(10):973-85.
  6. Jepsen S, Berglundh T, Genco R, Aass AM, Demirel K, Derks J et al. Primary prevention of peri-implantitis: managing peri-implant mucositis. J Clin Periodontol 2015;42(suppl.16):S152-7.
  7. Rodrigo D, Sanz-Sanchez I, Figuero E, Llodrá JC, Bravo M, Caffesse RG et al. Prevalence and risk indicators of peri-implant diseases in Spain. J Clin Periodontol 2018;45(12):1510-20.
  8. Menini M, Setti P, Pera P, Pera F, Pesce P. Peri-implant tissue health and bone resorption in patients with immediately loaded, implant-supported, full-arch prostheses. Int J Prosthodont 2018;31(4):327-33.
  9. Corbella S, Del Fabbro M, Taschieri S, De Siena F, Francetti L. Clinical evaluation of an implant maintenance protocol for the prevention of peri-implant diseases in patients treated with immediately loaded full-arch rehabilitations. Int J Dent Hyg 2011;9(3):216-22.
  10. Kita D, Kinumatsu T, Yokomizo A, Tanaka M, Egawa M, Makino-Oi A et al. Clinical effect of a dentifrice containing three kinds of bactericidal ingredients on periodontal disease: a pilot study in patients undergoing supportive periodontal therapy. BMC Res Notes 2018;11(1):116.
  11. James P, Worthington HV, Parnell C, Harding M, Lamont T, Cheung A et al. Chlorhexidine mouthrinse as an adjunctive treatment for gingival health. Cochrane Database Syst Rev 2017;3(3):CD008676.
  12. Chen WQ, Zhang SM, Qiu J. Surface analysis and corrosion behavior of pure titanium under fluoride exposure. J Prosthet Dent 2020;124(2):239.e1-239.e8.
  13. Haydari M, Bardakci AG, Koldsland OC, Aass AM, Sandvik L, Preus HR. Comparing the effect of 0.06% -, 0.12% and 0.2% chlorhexidine on plaque, bleeding and side effects in an experimental gingivitis model: a parallel group, double masked randomized clinical trial. BMC Oral Health 2017;17(1):118.
  14. Jenabian N, Moghadamnia AA, Karami E, Mir A PB. The effect of camellia sinensis (green tea) mouthwash on plaque-induced gingivitis: a single-blinded randomized controlled clinical trial. Daru 2012;20(1):39.
  15. Abdulbaqi HR, Himratul-Aznita WH, Baharuddin NA. Evaluation of salvadora persica L. and green tea anti-plaque effect: a randomized controlled crossover clinical trial. BMC Complement Altern Med 2016;16(1):493.
  16. Moghbel A, Farjzadeh A, Aghel N, Agheli H, Raisi N. Evaluation of the effect of green tea extract on mouth bacterial activity in the presence of propylene glycol. Jundishapur J Nat Pharm Prod 2012;7(2):56-60.
  17. Ni J, Shu R, Li C. Efficacy evaluation of hyaluronic acid gel for the restoration of gingival interdental papilla defects. J Oral Maxillofac Surg 2019;77(12):2467-74.
  18. Sahayata VN, Bhavsar NV, Brahmbhatt NA. An evaluation of 0.2% hyaluronic acid gel (Gengigel®) in the treatment of gingivitis: a clinical & microbiological study. Oral Health Dent Manag 2014;13(3):779-85.
  19. Casale M, Moffa A, Vella P, Sabatino L, Capuano F, Salvinelli B et al. Hyaluronic acid: perspectives in dentistry. A systematic review. Int J Immunopathol Pharmacol 2016;29(4):572-82.
  20. Dahiya P, Kamal R. Hyaluronic acid: a boon in periodontal therapy. N Am J Med Sci 2013;5(5):309-15.
  21. Abdulkareem AA, Al Marah ZA, Abdulbaqi HR, Alshaeli AJ, Milward MR. A randomized double-blind clinical trial to evaluate the efficacy of chlorhexidine, antioxidant, and hyaluronic acid mouthwashes in the management of biofilm-induced gingivitis. Int J Dent Hyg 2020;18(3):268-77.
  22. Loe H, Silness J. Periodontal disease in pregnancy. I. prevalence and severity. Acta Odontol Scand 1963;21:533-51.
  23. Silness J, Loe H. Periodontal disease in pregnancy. II. Correlation between oral hygiene and periodontal condition. Acta Odontol Scand 1964;22:121-35.
  24. Hrishi TS, Kundapur PP, Naha A, Thomas BS, Kamath S, Bhat GS. Effect of adjunctive use of green tea dentifrice in periodontitis patients – a randomized controlled pilot study. Int J Dent Hyg 2016;14(3):178-83.
  25. Hagiu A, Attin T, Schmidlin PR, Ramenzoni LL. Dose-dependent green tea effect on decrease of inflammation in human oral gingival epithelial keratinocytes: in vitro study. Clin Oral Investig 2020;24(7):2375-83.
  26. Chen M, Li L, Wang Z, Li P, Feng F, Zheng X. High molecular weight hyaluronic acid regulates P. gingivalis-induced inflammation and migration in human gingival fibroblasts via MAPK and NF-κB signaling pathway. Arch Oral Biol 2019;98:75-80.
  27. Figuero E, Roldán S, Serrano J, Escribano M, Martín C, Preshaw PM. Efficacy of adjunctive therapies in patients with gingival inflammation: a systematic review and meta-analysis. J Clin Periodontol 2020;47(suppl.22):125-43.
  28. Hu D, Li X, Liu H, Mateo LR, Sabharwal A, Xu G et al. Evaluation of a stabilized stannous fluoride dentifrice on dental plaque and gingivitis in a randomized controlled trial with 6-month follow-up. J Am Dent Assoc 2019;150(4S):S32-7.
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