Vinte anos de utilização de hemoderivados na Periodontia e Implantodontia: revisão de escopo

Ravi Aliguiere Reis Padilha de Menezes
Cirurgião-Dentista Faculdades integradas FAESA Técnico em prótese dentária APO Odonto Prótese. Membro da Sociedade Brasileira de Odontologia Estética – SBOE.
ORCID: 0009-0006-7438-4395.

DOI: https://doi.org/10.71440/2675-5610.10.6.25.770-773.art

RESUMO

Objetivos: Avaliar a utilização de hemoderivados nas áreas de Periodontia e Implantodontia ao longo dos últimos 20 anos, identificando os principais tipos, indicações clínicas e desfechos. Material e Métodos: Revisão de escopo conduzida segundo o protocolo PRISMA-ScR. A busca foi realizada nas bases PubMed, Scopus e Web of Science, com os descritores “Platelet-Rich Fibrin”, “Platelet-Rich Plasma”, “Fibrin”, “Growth Factors”, combinados com “Periodontics” e “Implantology”, usando os operadores booleanos AND/OR. Foram incluídos estudos clínicos, revisões sistemáticas e relatos de caso publicados entre 2004 e 2024, com foco em humanos e redigidos em inglês ou português. Critérios de exclusão incluíram estudos exclusivamente laboratoriais, artigos duplicados ou sem acesso ao texto completo. Resultados: Foram incluídos 17 artigos: 8 em Periodontia e 9 em Implantodontia. Os hemoderivados mais utilizados foram PRF, A-PRF, i-PRF, CGF e Sticky Bone. As aplicações clínicas variaram desde biomodificação radicular, preservação alveolar, controle de infecções periodontais até cicatrização óssea acelerada e manutenção de volume em implantodontia. A maioria dos estudos relatou desfechos positivos, como aumento da estabilidade dos implantes, redução de inflamação e maior previsibilidade regenerativa. Conclusão: O uso de hemoderivados autólogos representa uma estratégia segura, biocompatível e promissora nas abordagens regenerativas em Periodontia e Implantodontia. Contudo, ainda são necessários mais ensaios clínicos randomizados com padronização metodológica para que haja consenso em relação à indicação e eficiência dessas terapias.

Palavras-chave: Hemoderivados; PRF; Fatores de Crescimento; Agregados Plaquetários; Odontologia Regenerativa.

Twenty years of use of blood-derived products in periodontics and implant dentistry: a scoping review

ABSTRACT

Objectives: To evaluate the use of blood-derived products in the fields of Periodontics and Implant Dentistry over the past 20 years, identifying the main types, clinical indications, and outcomes. Material and Methods: A scoping review was conducted following the PRISMA-ScR protocol. A literature search was performed in the PubMed, Scopus, and Web of Science databases using the descriptors “Platelet-Rich Fibrin,” “Platelet-Rich Plasma,” “Fibrin,” and “Growth Factors” combined with “Periodontics” and “Implantology,” using the Boolean operators AND/OR. Included were clinical studies, systematic reviews, and case reports published between 2004 and 2024, involving human subjects and written in English or Portuguese. Exclusion criteria included purely laboratory studies, duplicate articles, inaccessible full texts, and studies related to prosthodontics. Results: A total of 17 articles were included: 8 in Periodontics and 9 in Implant Dentistry. The most commonly used blood-derived products were PRF, A-PRF, i-PRF, CGF, and Sticky Bone. Clinical applications ranged from root surface biomodification, socket preservation, and periodontal infection control to accelerated bone healing and volume maintenance in implant procedures. Most studies reported positive outcomes, such as increased implant stability, reduced inflammation, and greater regenerative predictability. Conclusion: The use of autologous blood-derived products represents a safe, biocompatible, and promising strategy in regenerative approaches in Periodontics and Implant Dentistry. However, further randomized clinical trials with standardized methodology are necessary to reach a consensus on their indications and effectiveness.

Keywords: Blood-derived products; PRF; Growth Factors; Platelet Aggregates; Regenerative Dentistry.

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